MBPhD projects available

Project 1: Investigating the roles of Polε in genome stability and sensitization to ATR and PARP inhibitors

Primary supervisor: Roberto Bellelli, Queen Mary University of London Co-supervisors: David Michod, UCL

Project 2: Unravelling the Role of ZEB1 in Chronic Lymphocytic Leukaemia Progression: Pathways to Novel Therapeutic Insights

Primary supervisor: Andrejas Braun, Sergey Krysov, Queen Mary University of London Secondary supervisor: Maxim Freydin, Queen Mary University of London

Project 3: A spatial biology approach to interrogate altered cellular interactions in promoting DCIS progression

Primary supervisor: Louise Jones, Queen Mary University of London Co-supervisor: Claude Chelala, Queen Mary University of London

Project 4: Investigating the mechanisms of and overcoming cell-mediated immunosuppression of CAR T cells, using in vitro multicellular models

Primary supervisor: John Marshal, Queen Mary University of London Co-supervisor: James Arnold, King’s College London

Project 5: Deciphering LIMD1’s Impact on Lung Cancer Progression and Therapeutic Response Using Novel Conditional Mouse Models

Primary supervisor: Tyson Sharp, Queen Mary University of London Secondary supervisor: Adam Januszewski, Queen Mary University of London,  Nicholas McGranahan, UCL

Project 1: Detection of blood TCR signatures associated with risk and precursors of high-grade serous ovarian cancer (HGSOC)

Primary supervisor: Filipe Correia Martins, UCL Co-supervisors: Aleksandra Gentry-Maharaj, UCL

Project 2: Defining early epigenetic drivers of breast cancer metastasis through development and validation of a methylation-Based biomarke

Primary supervisor: Nnenna Kanu, UCL Co-supervisors: Lucia Cottone, UCL

Project 3: The biological origin, diagnostic value and therapeutic exploitation of the C-terminus chromogranin A naturally modified fragments in pancreatic cancer

Primary supervisor: Nikolitsa Nomikou, UCL Co-supervisors: Marilena Loizidou, UCL

Project 4: Targeting TP53 in myeloid malignancies

Primary supervisor: Elspeth Payne, UCL Co-supervisors: Rob Sellar, UCL

Project 5: Immune interception strategies across pre-cancers using single-cell and spatial atlases

Primary supervisor: James Reading, UCL Co-supervisors: Nicholas McGranahan, UCL

Project 6: Deciphering protein-kinase C beta signalling in blood cancers

Primary supervisor: Ingo Ringshausen, UCL Co-supervisors: Pavel Tolar, UCL Collaborator: Neil McDonald, Francis Crick Institute