Cell and Vector Manufacturing2021-08-05T11:07:55+00:00

Cell and Vector Manufacturing Core

The Cell and Vector Manufacturing core is based at the Royal Free Hospital in Hampstead within the Centre for Cell, Gene & Tissue Therapeutics (CCGTT). The CCGTT comprises a large cleanroom facility for the manufacture of Advanced Therapeutic Medicinal Products (ATMPs) and is directed by Professor Mark Lowdell.

The cell manufacturing Core are responsible for translation of novel gene engineered and genome edited cellular therapies. The team have expertise in process development and GMP manufacturing for Phase I academic clinical studies.

There is a focus on semi-automated, closed cell manufacture and the core have a number of CliniMACS Prodigy platforms in current use.

The core is also bringing genome edited products to the clinic and are currently using the Lonza 4D-Nucleofector LV-Unit platform.

CliniMACS Prodigy workflow

CliniMACS Prodigy workflow

Lonza 4D-Nucleofector X-Unit

Lonza 4D-Nucleofector X-Unit

within the Centre for Cell, Gene & Tissue Therapeutics (CCGTT) clean rooms

CCGTT clean room


Amaia Garai
Amaia GaraiManufacture Scientist
Louisa Green
Louisa GreenManufacture Scientist

Academic Lead

Dr Claire Roddie
Dr Claire RoddieClinician Scientist