About Us2019-11-05T15:59:59+00:00

Vision – A CRUK Centre of Excellence in Biotherapeutics

Biotherapies delivered as part of a multimodal/combinatorial approach have the potential to dramatically change cancer therapy and management. The CRUK City of London Centre vision is to be at the forefront of cancer biotherapeutics in the UK and internationally, providing leadership for the wider CRUK Centres network.

The CRUK City of London Centre partners have contributed significantly to the field of intra-tumour heterogeneity and cancer evolution, elaborating its clinical significance and the unique challenges it poses for therapy of a dynamic tumour and its microenvironment. The CRUK City of London Centre will develop innovative biological therapies and diagnostics/stratification strategies working from an evolutionary and immunological perspective. We will explore the interplay between biological and other precision therapies to develop novel, potent and selective therapeutic combination approaches.


Through its platform-based approach the CRUK City of London Centre aims at becoming a CRUK-wide focus for the development, manufacture and precision application of biological therapies.

The CRUK City of London Centre partners are UCL, Barts/QMUL, King’s Health Partners and the Francis Crick Institute.

The CRUK City of London Centre is run by an Executive Board, who determine the strategy and budget allocations across the Centre. The committee is composed of representatives from each partner institution. The day-to-day operations of the Centre are carried out by a management team based in the UCL Cancer Institute.

The shared Major Centre vision is built on the commitment and engagement of the partners, their host Institutions, and the associated NHS Trusts. These are brought together at the highest level through the Major Centre’s Oversight Committee, comprising senior institutional representatives with an independent Chair.

The CRUK CoL Centre is funded by Cancer Research UK.

Executive Board

Professor Tariq Enver, UCL Cancer Institute Director

Professor Nick Lemoine, Director of Barts Cancer Institute

Professor Tony Ng, Head of School, School of Cancer and Pharmaceutical Sciences, King’s College London

Professor Charles Swanton, CRUK-UCL-Crick Clinical Cancer Medicine Lead

Professor Sir Richard Treisman, Research Director at the Francis Crick Institute

Oversight Committee

Professor Anton Berns, Former Research Director of the Netherlands Cancer Institute (Independent Chair)

Professor Sir Paul Nurse, Chief Executive and Director of the Francis Crick Institute

Professor Sir Robert Lechler, Vice-Principal (Health), Executive Director of King’s Health Partners

Professor David Lomas, Vice Provost (Health,) School of Life & Medical Sciences, UCL

Professor Steve Thornton, Vice Principal (Health), Executive Dean of the Barts and the London School of Medicine and Dentistry

Dr David Scott, Senior CRUK Representative

Science Advisory Board

The Scientific Advisory Board is external to the CRUK CoL Centre and provides advice to the Executive Management Board.

Professor Doreen Cantrell (Chair) – Professor of Cellular Immunology and Wellcome Trust Principal Research Fellow. School of Life Sciences, University of Dundee.

Dr John Shields – Director at JGSbiopharma Ltd

Professor Alison Noble – Technikos Professor of Biomedical Engineering and Associate Head of MPLS Division. Institute of Biomedical Engineering, University of Oxford

Professor Stephanie Combs – Professor and Chair of the Department of Radiation Oncology at the Technical University of Munich (TUM), Germany

Dr Jasmin Fisher – Principal Researcher at Microsoft Research Cambridge in the Programming Principles & Tools group and Associate Professor of Systems Biology in the Department of Biochemistry at the University of Cambridge

Professor Alberto Bardelli – Professor of Oncological Sciences at the University of Torino School of Medicine and Director of the Laboratory of Molecular Genetics at the Institute for Cancer Research and Treatment (Turin, Italy)

Professor Pamela Kearns – Professor of Clinical Paediatric Oncology,Institute of Cancer and Genomic Sciences, University of Birmingham and Honorary Consultant in Paediatric Oncology

Professor Josef Vormoor – Peadiatric oncologist in the Princess Máxima Center, Utrecht, Netherlands

Management Team

Leadership for the Centre is provided by the Centre Co-Directors in close collaboration with the Centre Senior Project Manager, Dr Cristina Aguilera Xiol, who is also responsible for coordinating and implementing Centre activity. The CRUK CoL Centre’s Core Management team are located in the UCL Cancer Institute in the Paul O’Gorman Building, Room 325/26.

Dr Cristina Aguilera Xiol – Senior Project Manager (Strategy and Science)

Contact : c.aguilera@ucl.ac.uk


The Francis Crick Institute


Comprehensive Cancer Centre / King’s Health Partners

CRUK Barts Centre / Queen Mary University of London