Cancer Evolution2021-11-09T10:52:15+00:00

Enhancing Impact of Therapy by Understanding Cancer Evolution

The Centre will address how we can impede the evolutionary resilience of cancer

The emergence of an evolutionary cancer perspective has major implications for cancer biology, patient management and clinical trial design. Through our collective strength in evolutionary biology, statistical genetics, molecular pathology and leadership of the Genomics England 100,000 genome project and the Genomics England Clinical Interpretation Partnership (GeCIP), we are well positioned to profile patients at diagnosis and throughout therapy, linking response to biomarkers and the integration of complex genomics and clinical datasets. The Centre’s collaborative Evolution computational and data resource will support the aims of the programme and enable cancer’s dynamics to be mapped longitudinally during exposure to biological therapies, integrated within the partners’ NHS service. 

T-cell leukaemia cells (mCherry fluorescent) infiltrating a zebrafish tail

Theme Leads

Professor Trevor Graham
Professor Trevor Graham
Professor Francesca Ciccarelli
Professor Francesca Ciccarelli
Dr Nicky McGranahan
Dr Nicky McGranahan

Explore our other Research Programmes

Novel Biological Therapies

Effective Therapy Combinations

Cancer Evolution

Early Detection and Prevention

Cross-cutting theme: Paediatric